The Substance 2025 Reviews 2022. We review the substance starring demi moore, margaret qualley, and dennis quaid, which made its north american premiere at tiff 2025. The substance — out september 20th — from writer / director coralie fargeat is a gruesome, feminist body horror for the age of ozempic.

The substance is a remarkable generational battle set in an era where beauty standards hang over women like the sword of damocles. Feeling crushed by impossible beauty standards and society’s hyperfixation.